Small molecule RNase inhibitors and methods of use

摘要

Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

主权项

1. A method of treating or preventing a microbial infection in a subject, comprising administering to the subject an effective amount of an RNase inhibitor of the following structure:or a pharmaceutically acceptable salt or prodrug thereof.