摘要 |
<p>The present invention is directed towards novel folate-conjugates of formula I wherein F is a folate or derivative thereof, Z1, Z2, Z3 are independently of each other C or N, S1 to S4 are independently of each other a single bond or a spacer, Ra, Ra', and Rb are donor groups and/or another group F, Rc is optionally another group F and n is 1 or 2. The invention further contemplates the corresponding metal-chelate complexes as well as pharmaceutical compositions thereof, and their uses in diagnostic imaging and radiotherapy.</p> |
申请人 |
MERCK EPROVA AG |
发明人 |
MOSER, RUDOLF;SCHIBLI, ROGER;MUELLER, CRISTINA MAGDALENA;GROEHN, VIOLA;MICHEL, URS;SPARR, CHRISTOF;MINDT, THOMAS LEIGHTON |