Polymethylmethacrylate bone cement

摘要

The subject matter of the invention is a curable composition for use as bone cement, in particular for augmentation of osteoporotic bone tissue, comprising at least one organic polymer and at least one monomer for radical polymerization, at least one particulate inorganic additive having a BET surface of at least 40 m2/g, whereby the additive comprises covalently bound hydroxyl groups, whereby the composition further comprises at least one fatty acid ester or a mixture of fatty acid esters. Another subject matter of the invention is the use of said composition for augmentation of osteoporotic bone tissue and particularly preferably for vertebroplasty, kyphoplasty, and augmentation of drill holes in osteoporotic bone tissue, as well as a kit for producing said composition.

主权项

1. A method of augmenting osteoporotic bone tissue, said method comprising applying a bone cement into said bone tissue, wherein the bone cement is curable and comprises a composition having the following ingredients:
a) at least one organic polymer; b) at least one monomer for radical polymerization; c) at least one polymerization initiator; d) at least one particulate inorganic additive having a BET surface of at least 200 m2/g, wherein the additive comprises covalently bound hydroxyl groups, and wherein the composition comprises the additive in a concentration of 0.02 to 0.14% by weight, based on a total weight of the composition; and e) one fatty acid ester or a mixture of fatty acid esters, wherein the one fatty acid ester or mixture of fatty acid esters is liquid at room temperature, and wherein the composition comprises the one fatty acid ester or mixture of fatty acid esters in a concentration of 1.0 to 6.0% by weight, based on a total weight of the composition.