| 发明名称 | Tyrosine kinase receptor TYRO3 as a therapeutic target in the treatment of cancer | ||
| 摘要 | The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer. | ||
| 申请公布号 | US9233144(B2) | 申请公布日期 | 2016.01.12 |
| 申请号 | US200913062804 | 申请日期 | 2009.09.18 |
| 申请人 | INSTITUT CURIE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;ASSISTANCE PUBLIQUE HOPITAUX DE PARIS;UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE | 发明人 | Bernard-Pierrot Isabelle;Radvanyi Francois;Allory Yves;Stransky Nicolas |
| 分类号 | A61K6/00;A61K31/00;A61K31/70;A61K31/7088;A61K31/713;A61K38/00;A61K38/16;A61K38/43;A61K38/45;C07K16/30;C12N15/113;A61K45/06;C12Q1/48;G01N33/50;G01N33/574 | 主分类号 | A61K6/00 |
| 代理机构 | Saliwanchik, Lloyd & Eisenschenk | 代理人 | Saliwanchik, Lloyd & Eisenschenk |
| 主权项 | 1. A method for treating a subject having a TYRO3 over-expressing cancer comprising administering a therapeutically effective amount of a composition comprising a TYRO3 inhibitor to a subject having a cancer that overexpresses TYRO3 tyrosine kinase, wherein the TYRO3 over-expressing cancer is selected from the group consisting of bladder cancer, diffuse large B-cell lymphoma, adenoid cystic carcinoma of the salivary gland, Burkitt's lymphoma, multiple myeloma, pancreatic ductal adenocarcinoma, hairy cell leukemia, metastatic prostate cancer, melanoma, and colorectal cancer, and wherein, in the TYRO3 over-expressing cancer, TYRO3 is over-expressed by comparison to normal cells provided from the same tissue as the TYRO3 over-expressing cancer. | ||
| 地址 | Paris FR | ||