发明名称 |
Recombinant human interferon-like proteins and method of treatment using them |
摘要 |
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human inteferon like alpha 2b(HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer. |
申请公布号 |
US9234022(B2) |
申请公布日期 |
2016.01.12 |
申请号 |
US201313841679 |
申请日期 |
2013.03.15 |
申请人 |
Novagen Holding Corporation |
发明人 |
Wang Haitao;Mao Chunsheng;Li Jizhi;Wang Ling;Du Yong;Liu Longbin;Xu Jing;Zhang Rui |
分类号 |
A61K38/21;C07K14/00;C08H1/02;C07K14/56;C07K14/555;C12P21/04;C07H21/04;A61K38/00 |
主分类号 |
A61K38/21 |
代理机构 |
Seed IP Law Group PLLC |
代理人 |
Seed IP Law Group PLLC |
主权项 |
1. A non-naturally occurring protein exhibiting human interferon-like biological activities, wherein said protein is selected from the group consisting of proteins each comprising an amino acid sequence at least 89% identical to SEQ ID No: 2. |
地址 |
George Town KY |