Blood lactate range targets and nutritional formulations and protocols to support patients

摘要

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.

主权项

1. A method of addressing the nutritional status of a human patient, the method comprising:
(a) determining a blood lactate concentration of the patient; and (b) based on the determining in (a), if the blood lactate concentration is less than about 2.0 mM, providing or increasing a first nutritional support, or if the blood lactate concentration is greater than about 4.0 mM, decreasing or ceasing a second nutritional support; wherein the patient is injured or ill.