| 主权项 |
1. A recombinant protein covalently conjugated to at least one hydrophobic side group having the formula:
(A-W-B1-B2)z-asialoProtein wherein: asialoProtein represents a protein in which the terminal sialic acid has been removed from a glycan; z represents an integer of the value 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; B2 represents a glycyl-sialic acid having the structure wherein R1, R1′, R2, R3, R4, R5, and R6 are either a bond connecting B2 with B1 or a hydrogen and * denotes the connection to asialoProtein; B1 represents a linker; W represents a chemical group linking A and B1; and A represents a hydrophobic albumin binding side group, wherein the side group is derived from substrate 1, 3 or 4; wherein substrate 1 is wherein substrate 3 isand
wherein substrate 4 is |
