| 摘要 |
The invention relates to the field of biomedical and pharmacological research, in particular in the field of immunology, allergies, cancers, bone diseases and autoimmune diseases.;The invention is based on the recent finding that SWAP-70 dimerises, that the dimerisation takes place via a specific, largely unique and limited region of the protein, and that this dimerisation is central to the function of the protein (and probably the stability thereof).;The invention provides a screening method which makes it possible to identify new active ingredients which, by accumulating at the dimerisation domain and inhibiting SWAP-70 activity, suppress the supporting function of SWAP-70 in tumourigenesis, tumour cell migration and invasion, bone-degrading osteoclast activity, and the allergic reaction, as well as in autoimmune diseases.;The object is achieved by a method for identifying a substance which inhibits the activity of SWAP-70, wherein the method comprises the following: contacting at least one test substance with SWAP-70, detecting the degree of dimerisation of SWAP-70, selecting a test substance which inhibits the dimerisation of SWAP-70. |
