| 摘要 |
A system and method of determining the estimated glomerular filtration rate of the kidneys of a patient. The system and method obtains patient medical data, determines constants based on the patient medical data and using exactly one of the MDRD equation or the Cockroft-Gault equation, and determines the estimated glomerular filtration rate based on a relationship of measured creatinine levels and the determined constants. The estimated glomerular filtration rate is used to determine the dose of a medication of a type filtered by the kidneys, determine a temporal correlation of the introduction of a drug into a patient with changes in kidney function, determine the administration rate for dosing intravenous fluids, determine the efficacy of a medical treatment, and determine kidney function after transplantation or injury. |
| 主权项 |
1. A computer-implemented method of determining a dose of a medication of a type that is filtered by the kidneys, comprising:
accessing an electronic medical record that includes one or more medical data selected from
an age of a patient,a gender of the patient,a weight of the patient,an ethnicity of the patient,a first measured creatinine level, Cr1, at a first time, anda second measure creatinine level, Cr2, at a second time; determining an estimated glomerular filtration rate of the kidneys of the patient based at least in part on the relationshipCr2=A-(A-B*Cr1)*(-B*t)B;and
determining the dose of the medicine for the patient based at least in part on the estimated glomerular filtration rate of the kidneys of the patient, wherein t is the interval between the first time and the second time, wherein A is a constant determined from the medical data applied to exactly one of the MDRD equation or the Cockcroft-Gault equation, and wherein B is a constant, determined from the medical data applied to exactly one of the MDRD equation or the Cockcroft-Gault equation, that is multiplied by the estimated glomerular filtration rate over the interval. |
