| 发明名称 |
RECOMBINANT ANTIGENS OF PORCINE CIRCOVIRUS 2 (PCV-2) FOR VACCINE FORMULATIONS, DIAGNOSTIC KIT AND USE THEREOF |
| 摘要 |
The present invention relates to the preparation of the recombinant antigen of the viral capsid of Porcine circovirus 2 (PCV-2) and modifications thereof, upon expression in a prokaryotic system, purification in the monomer form, recovery of virus-like particles (VLPs) and their use in vaccine formulations, diagnostic kits and a system for quantifying in vaccine lots of the PCV-2 antigen by means of a capture ELISA assay. The antigens and vaccine formulations can be used in animal's immunization in programs for combatting PCV-2-associated diseases in conventional swine breeding systems, and represent alternatives to the commercially available vaccines. The ELISA kit can be used for testing the quality of commercial and/or experimental vaccines against PCV-2. |
| 申请公布号 |
US2016000897(A1) |
申请公布日期 |
2016.01.07 |
| 申请号 |
US201414763121 |
申请日期 |
2014.01.23 |
| 申请人 |
FOUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIG ;UNIVERSIDADE FEDERAL DE VIÇOSA |
发明人 |
DE ALMEIDA Márcia Rogéria;JUNIOR Abelardo Silva;FIETTO Juliana Lopes Rangel;BRESSAN Gustavo Costa;SALGADO Rafael Locatelli;ONOFRE Thiago Souza;FAUSTO Mariana Costa;VIDIGAL Pedro Marcus Pereira;KALKS Sthefany Patareli;CRISPIM Josicelli Souza;AMAZILES SILVA LEITE Roberta;ANDRADE TEIXEIRA Jackson de;FIALHO GONZAGA Natália;JAQUEL ZILCH Tiago;LINO DE SOUZA Luiz Fernando;DE CRUZ SOUZA Amanda Martins;DE MORAIS MONTEIRO Antônio |
| 分类号 |
A61K39/12;G01N33/569;C07K14/005 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. Recombinant antigen of the porcine circovirus 2 which is the SEQ ID NO: 02. |
| 地址 |
Belo Horizonte - MG BR |
