IMMUNOGENIC PRODUCTS BASED ON MUTEIN AMYLOID beta (Abeta) AMINO ACID SEQUENCES AND USES THEREOF

摘要

The invention relates to immunogenic products based on mutein amyloid β (Aβ) amino acid sequences, in particular to oligomers of Aβ muteins, and to the use of said products in diagnosis, treatment and prevention of conditions such as amyloidoses, and for identifying agents capable of binding to said products.

主权项

1. An immunogenic product comprising an amyloid β (Aβ) amino acid sequence having 62.5% or higher identity to the amino acid sequence V18F19F20A21E22D23V24G25S26N27K28G29A30I31I32G33 (SEQ ID NO: 2), wherein the product
i) is reactive with a monoclonal antibody selected from the group consisting of monoclonal antibody 7C6 obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7240; monoclonal antibody 4D10 obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7405, or monoclonal antibody 5F7 obtainable from a hybridoma designated by American Type Culture Collection deposit number PTA-7241; and ii) is capable of eliciting a polyclonal antiserum which has no or low cross-reactivity to platelet factor 4 (PF-4).