发明名称 |
A method of increasing GiPCR signalization in the cells of a scoliotic subject |
摘要 |
There is provided a method of increasing GIPCR signalization in the cells of a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of integrin alpha5betal expression and/or activity, whereby GiPCR signalization is increased in the cells of the subject. An inhibitor of integrin alph5betal may be, for example, an agent that inhibits the interaction between f osteopontin (OPN) and integrin alpha5betal. Also provided are methods of determining the risk of developing a scoliosis and based on the presence of at least one copy of a CD44 risk allele and methods of stratifying a subject having a scoliosis and kits for performing these methods. In particular, the method of determining risk identifies SNP rsl467558; an isoleucine to threonine mutation at position 230 of CD44. |
申请公布号 |
AU2014284079(A1) |
申请公布日期 |
2016.01.07 |
申请号 |
AU20140284079 |
申请日期 |
2014.06.17 |
申请人 |
CHU SAINTE-JUSTINE |
发明人 |
MOREAU, ALAIN;AKOUME NDONG, MARIE-YVONNE |
分类号 |
A61K39/395;A61K31/713;A61P19/08;C07H21/00;C12Q1/68;G01N33/48;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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