METHOD AND APPARATUS OF AIDING DETECTION OF SURFACE ABNORMALITY IN THE OESOPHAGUS

摘要

The invention relates to a method of aiding detection of a surface abnormality in the oesophagus of a subject, wherein said surface abnormality is selected from the group consisting of low-grade dysplasia (LGD), high-grade dysplasia (HGD), asymptomatic oesophageal adenocarcinoma (OAC) and intra-mucosal cancer (IMC), the method comprising:
a) providing a sample of cells from said subject, wherein said sample comprises cells collected from the surface of the subject's oesophagus;b) assaying said cells for at least two markers selected from
(i) p53;(ii) c-Myc;(iii) AURKA or PLK1, preferably AURKA; and(iv) methylation of MyoD and Runx3;

wherein detection of abnormal levels of at least two of said markers infers that the subject has an increased likelihood of a surface abnormality in the oesophagus. The invention also relates to certain kits, apparatus and uses.

主权项

1. A method of aiding detection of a surface abnormality in the oesophagus of a subject, wherein said surface abnormality is selected from the group consisting of low-grade dysplasia (LGD), high-grade dysplasia (HGD), asymptomatic oesophageal adenocarcinoma (OAC) and intra-mucosal cancer (IMC), the method comprising:
a) providing a sample of cells from said subject, wherein said sample comprises cells collected from the surface of the subject's oesophagus; b) assaying said cells for at least two markers selected from (i) p53; (ii) c-Myc; (iii) AURKA or PLK1, preferably AURKA; and (iv) methylation of MyoD and Runx3; wherein detection of abnormal levels of at least two of said markers infers that the subject has an increased likelihood of a surface abnormality in the oesophagus.