ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME

摘要

The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

主权项

1. An isolated polypeptide factor X derivative comprising:
1) a modified active site, and 2) a modified Gla domain or a deleted Gla domain; wherein the derivative binds to a factor Xa inhibitor and does not assemble into a prothrombinase complex.