| 主权项 |
1. A compound having the general formula Ior a pharmaceutically acceptable salt thereof, wherein:
R1 is hetAr1(CH2)m—, hetAr2CH2— or hetAr3CH2; hetAr1 is a 6-membered heteroaryl having 1-2 ring N atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl, (1-4C)alkoxy, halogen, CF3, or (3-6C)cycloalkyl; m is 0, 1 or 2; hetAr2 is a 5-membered heteroaryl ring having 2-3 ring heteroatoms independently selected from N and S where at least one of said heteroatoms is N, wherein said ring is optionally substituted with one or more substituents independently selected from (1-6C)alkyl; hetAr3 is a bicyclic 5,6-fused heteroaryl ring having two ring nitrogen atoms; R2 is CH3; R3 is H; R4 is H; R5 is hetCyc4(1-4C)alkoxy or hetCyc5(1-4C)alkoxy; hetCyc4 is a 4-7 membered heterocycle having 1-2 ring heteroatoms independently selected from N, O and S, wherein one of said ring nitrogen atoms is optionally oxidized to N(O) and wherein said S ring atom is optionally oxidized to SO or SO2, wherein hetCyc4 is optionally substituted with one or more substituents independently selected from halogen, OH, (1-6C)alkyl, (1-4C alkoxy)(1-6C)alkyl, (1-4C)alkyl-OC(═O)— and (1-6C)alkoxy; hetCyc5 is a spiro heterocycle having 2 ring heteroatoms independently selected from N and O, wherein hetCyc5 is optionally substituted with a group selected from (1-6C)alkyl; and R6 is H. |
