ANTICANCER COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF

摘要

The invention disclosed herein relates to novel Peribysin E analogues of general formula-I. Further the invention provides simple, economical and short synthesis of Peribysin E and its analogues of Formula I, in good yield and purity leading to the identification of more potent cell adhesion inhibitors.;

主权项

1. A compound of formula 1 wherein; R is hydrogen or (C1-C8) alkyl, R1, R2, and R3 each are individually selected from the group consisting of H, OH, OR or R1 and R2 together may form 4-8 membered alicyclic, aromatic ring which may additionally contain an hetero atom, or R1 and R2 together form epoxide ring; R4 and R5 are selected from hydrogen, C1-C8 alkyl, CONR2, COOR; or R4 and R5 may form 4-8 membered alicyclic ring which may additionally contain heteroatom.