WIDE FIELD RAMAN IMAGING APPARATUS AND ASSOCIATED METHODS

摘要

Apparatus and methods are presented herein that permit real-time, accurate detection of residual tumor in the operating room. The Raman-based wide-field imaging apparatus and methods described herein permit real-time imaging of tumor-targeted R-MR nanoparticles over a wide field.

主权项

1. A wide field Raman imaging apparatus comprising:
at least one light source for producing excitation light; optics for directing the excitation light onto and/or into a target tissue; a detector for detecting Raman scattered photons emanating from the target tissue following illumination by the excitation light, the Raman scattered photons indicative of the presence of a Raman reporter in and/or upon the target tissue; and a processor configured to process data corresponding to the Raman scattered photons detected from the target tissue and to produce an image depicting a wide field corresponding to the target tissue, the image visually indicating position and/or intensity of the Raman reporter within the wide field.