| 主权项 |
1. A compound having a structure: wherein Z is a heteroaryl group or RaRbNCO—; Y1 and Y2, independently, are N or CRc; Y3 and Y4, same or different, are each CRd; X1, X2, and X3, independently, are N or CR3, wherein at least one of X1, X2, and X3 is N; A is cycloalkyl, heterocycyl, aryl, or heteroaryl; L′ is J-(CH2)n—K, wherein n is an integer 3, 4, 5, 6, 7, 8, or 9, J-(CH2)m—N(R7)—(CH2)p—K, wherein m and p, independently, are integers 0, 1, 2, 3, 4, 5, or 6, and R7 is H, methyl, ethyl, propyl or butyl, (CH2O)l, (CH2CH2O)l, wherein l is 5, 6, 7, 8, or 9, —(NHCHRC(═O)—)q, wherein R, independently, is an amino acid residue, and q is an integer 3, 4, 5, 6, 7, 8, or 9; J and K, independently, are (—C(═O)—, —C(═O)N—, —SO2—, or —CH2—; R1 is hydrogen, a halo, cyano, C1-6alkyl, C2-7alkenyl, carbamoyl, or C2-7 alkynyl optionally substituted with a C1-4acyl group; R2 is C1-6alkyl optionally substituted with halo, OH, C1-6C(═O)Ra, or CH2OC1-6alkyl; R3 is hydrogen or C1-6alkyl; R4 and R5, independently are hydrogen or C1-6alkyl, or R4 and R5 are taken together with the carbon to which they are bound to form C1-6alkylene, C1-6heteroalkylene, C2-6alkenylene, or C2-6heteroalkenylene; R6, independently, is cyano, halo, nitro, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C6-14aryl, C7-15aralkyl, heteroaryl, heterocyclyl, —C(O)Re, —C(O)ORe, —C(O)N(Re)2, —C(NRe)N(Re)2, —ORe, —OC(O)Re, —OC(O)ORe, —OC(O)N(Re)2, —OC(═NRe)N(Re)2, —OS(O)Re, —OS(O)2Re, —OS(O)N(Re)2, —OS(O)2N(Re)2, —N(Re)2, —NReC(O)Re, —NReC(O)N(Re)2, —NReC(═NRe)N(Re)2, —NReS(O)Re, —NReS(O)2Re, —NReS(O)N(Re)2, —NReS(O)2N(Re)2, —SRe, —S(O)Re, —S(O)2Re, —S(O)N(Re)2, or —S(O)2(NRe)2, wherein q is 0, 1, 2, or 3; Ra and Rb, independently, are hydrogen, C1-6alkoxy, C3-8cycloalkyl, or a C1-6alkyl optionally substituted with a substituent selected from the group consisting of cyano, halo, hydroxy, C1-6alkoxy, and —N(Rf)2, or Ra and Rb are taken together with the nitrogen to which they are attached to form a heterocyclyl ring; Rc is hydrogen, halo, C1-6 alkyl, C1-4acyl, C1-4acyloxy, or —N(Rg)2; Rd is hydrogen, halo, or C1-6alkyl; Re, independently, is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C6-14aryl, C7-15aralkyl, heteroaryl, or heterocyclyl; Rf, independently, is hydrogen or C1-6alkyl; and Rg, independently, is hydrogen or C1-4acyl; or a pharmaceutically acceptable salt thereof. |
