| 发明名称 |
ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF |
| 摘要 |
Described herein are antimicrobial compounds identified via a high-throughput screen to identify compounds that produce anucleate cells in E. coli after cell division occurs. Compound 1 (5-nonyloxytryptamine) and its analogs are small molecule inhibitors of the nucleoid occlusion system and/or proteins that are responsible for maintaining the structure of the chromosome. The antimicrobial compounds are useful to treat bacterial infections as well as to inhibit bacterial growth. |
| 申请公布号 |
US2016002163(A1) |
申请公布日期 |
2016.01.07 |
| 申请号 |
US201514790380 |
申请日期 |
2015.07.02 |
| 申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
WEIBEL DOUGLAS BENJAMIN;HURLEY KATHERINE ANN;FAULKNER KATHERINE CASSIDY |
| 分类号 |
C07D209/16;C07C217/60;A01N43/38;A01N33/10;A61K31/4045;A61K31/137 |
主分类号 |
C07D209/16 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antimicrobial compound selected from |
| 地址 |
MADISON WI US |
