REAGENT FOR DIAGNOSIS OF OSTEOARTHRITIS COMPRISING PEPTIDE PROBE OF APOPEP-1

摘要

Disclosed is a reagent for diagnosing osteoarthritis or predicting the prognosis of osteoarthritis, the reagent containing a peptide having the amino acid sequence (CQRPPR) of SEQ ID NO: 1 as an active ingredient. The present peptide can be used to accurately diagnose osteoarthritis in its early stage based on the molecular imaging technique. The present peptide has a small molecular weight, and thus has advantages of fast clearance from the blood, effective permeation into the tissue, low immunogenicity, and low-production cost. Further, the present reagent can diagnose osteoarthritis in its early stage in which the destruction of cartilage is in a reversible phase and thus can be recovered to a normal state, thereby significantly contributing to effective treatment of osteoarthritis.

主权项

1. A method for detecting osteoarthritis of a subject comprising:
(a) administering to the subject or chondrocytes obtained from the subject a peptide probe containing (i) a peptide comprising the amino acid sequence of SEQ ID NO: 1 and (ii) a label generating a detectable signal and linked to the peptide; (b) determining the level of the peptide in the subject or the chondrocytes by measuring signal generated from the peptide probe; and (c) comparing the level of the peptide in the subject or chondrocytes, with the level of the peptide in a normal subject or normal chondrocytes, wherein an increased level of the peptide in the subject indicates an increased severity of osteoarthritis of the subject.