COMPOSITIONS AND METHODS TO ALTER GUT MICROBIAL FERMENTATION USING SULFATE-REDUCING BACTERIA

摘要

The present invention provides combinations and methods for changing the representation of at least one sulfate-reducing bacterial species in a subject's gut, thereby changing microbial fermentative activity in the gut in the subject.

主权项

1. A method for increasing microbial fermentative activity in the gut of a subject in need thereof, the method comprising administering a combination comprising a sulfated polysaccharide and an effective amount of at least one isolated Desulfovibrio species, wherein the at least one isolated Desulfovibrio species comprises at least one nucleic acid with at least 80% identity to a nucleic acid selected from the group consisting of DpigGOR1—1496 (SEQ ID NO: 1), DpigGOR1—1497 (SEQ ID NO: 2), DpigGOR1—0739 (SEQ ID NO: 3), DpigGOR1—0740 (SEQ ID NO: 4), DpigGOR1—1393 (SEQ ID NO: 5), DpigGOR1—1398 (SEQ ID NO: 6), DpigGOR1—0741 (SEQ ID NO: 7), DpigGOR1—0744 (SEQ ID NO: 8), DpigGOR1—0790 (SEQ ID NO: 9), DpigGOR1—0792 (SEQ ID NO: 10), DpigGOR1—0170 (SEQ ID NO: 11), and DpigGOR1—0174 (SEQ ID NO: 12).