USE OF ITK INHIBITORS FOR THE TREATMENT OF CANCER

摘要

This invention relates generally to the use of ITK (IL-2 inducible T-cell kinase) inhibitors for the treatment of patients who have melanoma or other solid tumors. Applicants demonstrate that ITK lentiviral small hairpin RNA knockdowns and a small molecule inhibitor can each decrease the proliferation and migration of melanoma cell lines and a small molecule inhibitor can be used to inhibit the growth of melanomas in vivo.

主权项

1. A method of inhibiting the growth of a solid tumor in a subject which comprises administering an effective amount of a selective interleukin-2 inducible T-cell kinase (ITK) inhibitor to the subject.