METHODS FOR THE TREATMENT OF MITOCHONDRIAL DISEASE

摘要

The disclosure provides methods of preventing, ameliorating or treating disruption of mitochondrial function and symptoms thereof. The methods provide administering aromatic-cationic peptides in effective amounts to prevent, treat or ameliorate the disruption of mitochondrial oxidative phosphorylation in a cell such as that found in a subject suffering from, or predisposed to a mitochondrial disease or disorder. In some embodiments, the methods comprise administering to a subject suffering from, or at risk for a mitochondrial disease or disorder, an effective amount of an aromatic-cationic peptide to subjects in need thereof.

主权项

1. A method for treating a mammalian cell with a disruption of mitochondrial oxidative phosphorylation, wherein the disruption of mitochondrial oxidative phosphorylation is associated with at least one gene mutation, the method comprising: contacting the cell with a therapeutically effective amount of the peptide D-Arg-2′,6′-Dmt-Lys-Phe-NH2 or a pharmaceutically acceptable salt thereof, thereby treating or ameliorating the disruption of oxidative phosphorylation in the cell.