发明名称 NEOSEPTINS: SMALL MOLECULE ADJUVANTS
摘要 A MD-2:TLR4 complex agonist compound is disclosed whose structure corresponds to Formula (I), as defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.;
申请公布号 US2016000907(A1) 申请公布日期 2016.01.07
申请号 US201414770002 申请日期 2014.02.25
申请人 THE SCRIPPS RESEARCH INSTITUTE ;THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 发明人 BEUTLER Bruce;BOGER Dale L.
分类号 A61K39/39;C07C237/20 主分类号 A61K39/39
代理机构 代理人
主权项 1. A compound that corresponds in structure to Formula I, below, or its pharmaceutically acceptable saltwherein X is O, S, NR1, CH2, where R1 is H, or C1-C4 hydrocarbyl, or X is absent and two atoms link the depicted phenyl rings; Y is O, S, NR2, CH2, where R2 is H, or a C1-C4 hydrocarbyl group; R3 is a C1-C6 hydrocarbyl group; R4 and R5 are hydrido or hydroxyl but only one of R4 and R5 is hydrido, or both of R4 and R5 are hydroxyl; W is a ring structure that contains one or two rings and includes 5 to 12 atoms in the ring structure, said ring structure W optionally containing: a) 1, 2, 3 or 4 heteroatoms in the ring structure that are independently oxygen, nitrogen or sulfur, and b) one or more substituent groups bonded to one or more ring atoms, in which said one or more substituents contain a total of up to 8 atoms, selected from the group consisting of fluorine, chlorine, carbon, nitrogen, oxygen and sulfur, and mixtures thereof; and a dotted line (----) represents one or more optional double bonds.
地址 La Jolla CA US