| 发明名称 |
COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES |
| 摘要 |
A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product. |
| 申请公布号 |
US2016000889(A1) |
申请公布日期 |
2016.01.07 |
| 申请号 |
US201514613882 |
申请日期 |
2015.02.04 |
| 申请人 |
Auxilium US Holdings, Inc. ;BioSpecifics Technologies, Corp. |
发明人 |
Sabatino Gregory L.;Del Tito, JR. Benjamin J.;Bassett Phillip J.;Tharia Hazel A.;Hitchcock Antony G.;Yu Bo;Wegman Thomas L. |
| 分类号 |
A61K38/48;C12N9/52 |
主分类号 |
A61K38/48 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A drug product comprising isolated and purified collagenase I and collagenase II having the sequence of Clostridium histolyticum collagenase I and collagenase II, respectively, wherein the collagenase I and collagenase II have a mass ratio of about 1 to 1 and the drug product is at least 95% by area pure as determined by reverse phase high performance liquid chromatography. |
| 地址 |
Wilmington DE US |
