发明名称 |
SMALL MOLECULES THAT ENHANCE THE ACTIVITY OF OLIGONUCLEOTIDES |
摘要 |
Methods of administering an oligonucleotide of interest into a cell in vitro or in vivo are described. In the methods, a small organic compound active agent is concurrently administered to the cell in an amount effective to increase the delivery of the oligonucleotide into the cell, and/or increase the activity of said oligonucleotide in the cell. Compositions useful for carrying out the method are also described. |
申请公布号 |
WO2016003816(A1) |
申请公布日期 |
2016.01.07 |
申请号 |
WO2015US38058 |
申请日期 |
2015.06.26 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;SOUTHERN RESEARCH INSTITUTE |
发明人 |
JULIANO, RUDOLPH;JANZEN, WILLIAM P.;MADDRY, JOSEPH A.;CAO, CANHONG;MING, XIN;YANG, BING |
分类号 |
C07D241/36;A61K31/4985;A61K31/713;C12N15/11 |
主分类号 |
C07D241/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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