OPHTHALMIC EXAMINATION AND DISEASE MANAGEMENT WITH MULTIPLE ILLUMINATION MODALITIES

摘要

Imaging various regions of the eye is important for both clinical diagnostic and treatment purposes as well as for scientific research. Diagnosis of a number of clinical conditions relies on imaging of the various tissues of the eye. The subject technology describes a method and apparatus for imaging of the back and/or front of the eye using multiple illumination modalities, which permits the collection of one or more of reflectance, spectroscopic, fluorescence, and laser speckle contrast images.

主权项

1. An ophthalmic imaging device, comprising:
A) an illumination module capable of generating a plurality of illumination modalities, wherein the illumination modalities include coherent illumination and incoherent illumination, and wherein the illumination module is configured to perform one or more of laser speckle contrast imaging, spectroscopic imaging, reflectance imaging, or fluorescence imaging; B) one or more imaging sensors configured to collect light from one or more regions of tissue of the eye; C) (i) an optical assembly comprising one or more optical elements configured to direct light from the illumination module to the one or more regions of tissue of the eye, and further configured to direct light from the one or more regions of tissue of the eye to the one or more imaging sensors; or (ii) a first optical assembly comprising one or more first optical elements configured to direct light from the illumination module to the one or more regions of tissue of the eye and a second optical assembly comprising one or more second optical elements configured to direct light from the one or more regions of tissue of the eye to the one or more imaging sensors; and D) one or more processors configured to calculate laser speckle contrast values for pixels of the one or more imaging sensors associated with the one or more regions of tissue of the eye, wherein the calculated laser speckle contrast values use properties of a pixel's neighborhood of pixels in spatial or temporal domains; wherein the one or more regions of the tissue of the eye include the retina, choroid, the cornea, the sclera, and the eye lens; wherein the one or more optical elements, the one or more first optical elements, and/or the one or more second optical elements is an aperture that results in the production of a speckle pattern on the one or more imaging sensors.