SUBSTITUTED PYRROLO[2,3-d]PYRIMIDINES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS

摘要

Disclosed are substituted pyrrolo[2,3-d]pyrimidine compounds. The disclosed compounds are shown to be useful in inhibiting the growth of cancer cell lines and treating cancer and cell proliferative disorders.

主权项

1. A compound having a Formula I:wherein: R2 is hydrogen, halogen, or amino; R4 is hydrogen, hydroxyl, halogen, acetyl, amino, methylsulfonyl, acetyl, cyano, or C1-C3 alkyl optionally substituted at one or more positions with halogen; R5 and R6 are each independently hydrogen, halogen, amino, or C1-C3 alkyl optionally substituted at one or more positions with halogen; or R5 and R6 are linked together to form a 6-membered ring, which optionally is a carbocyclic ring; R7 is N or (CH2)n where n is 0, 1, 2, or 3; R8 is hydrogen, C1-C3 alkyl optionally substituted at one or more positions with halogen, C1-C3 alkoxy, amino, or a 4-, 5-, or 6-membered carbocyclic or heterocyclic ring that is saturated or unsaturated, the carbocyclic or heterocyclic ring optionally substituted at one or more carbon atoms with halogen, hydroxyl, methoxy, oxo, methylcarboxyl, methylamido, or methylhydroxyl; and the heterocyclic ring is optionally substituted at a nitrogen heteroatom with a substituent selected from C1-C3 alkyl,or R8 is selected from