ANTIVIRAL COMPOUNDS

摘要

The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.;

主权项

1. A compound of formula I: wherein: A is phenyl, naphthyl, or bicyclic unsaturated or partially saturated heteroaryl, optionally substituted with one or more A′; each A′ is independently lower alkyl, halo, lower alkoxy, S(═O)2(CH2)mA″, C(═O)NHA″, NHC(═O)A″, —O(CH2)mA″, (CHA1)mNHS(═O)2A1; or S(═O)2NHA″; each A″ is independently lower alkyl, heterocycloalkyl or heteroaryl, optionally substituted with one or more A′″; each A′″ is independently hydroxy, lower alkyl, oxo, C(═O)OA1, halo loweralkyl, each A1 is independently H, lower alkyl, halo loweralkyl, amino, lower alkoxy, each m is independently 0, 1, 2, or 3; R1 is H, halo, lower alkyl, halo loweralkyl, SF5, and R2 is H, halo, lower alkyl, halo loweralkyl, or a pharmaceutically acceptable salt thereof.