| 发明名称 |
COMPOSITION FOR EX VIVO CULTURING OF A CORNEAL ENDOTHELIAL CELL AND A METHOD FOR USING THE COMPOSITION |
| 摘要 |
A composition for ex vivo culture of corneal endothelial cell and a method for used the composition are disclosed. The composition or the method is applied to ex vitro culture of the corneal endothelial cell to maintain the corneal endothelial cell in a hexagonal phenotype, and to prevent the corneal endothelial cell from endothelial-mesenchymal transformation (EnMT). Therefore, the corneal endothelial cell can maintain normal phenotype and function and can be used in the further application. The composition at least comprises an effective concentrated matrix metalloproteinase inhibitor (MMPI). |
| 申请公布号 |
US2016002596(A1) |
申请公布日期 |
2016.01.07 |
| 申请号 |
US201514791401 |
申请日期 |
2015.07.03 |
| 申请人 |
National Taiwan University |
发明人 |
Wang I-Jong;Ho Wei-Ting;Chiang Ting-Hsuan;Lin I-Tsen |
| 分类号 |
C12N5/079 |
主分类号 |
C12N5/079 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A growth regulator for ex vivo culturing of a corneal endothelial cell, at least comprises an effective concentrated matrix metalloproteinase inhibitor (MMPI). The regulator is added in the culture medium to maintain the phenotype and function of corneal endothelial cells and prevent the cells from endothelial-mesenchymal transformating and loss of function. |
| 地址 |
Taipei TW |
