| 摘要 |
There is disclosed a composition formed by a reaction of at least one component A and at least one component B, wherein component A is selected from among a compound comprising having at least two thiol-groups and a disulfide derivative of a compound having at least two thiol groups, and wherein component B is a compound having at least two vinyl reactive groups, for the manufacture of an implant for the treatment of a bone fracture. Advantages include that the adhesive patch formed by the composition will be solid in body fluid upon curing and will exhibit excellent mechanical strength. Advantages include that the composition is biocompatible, the material can be applied in small and inaccessible areas, the process requires less surgeon training, it solves drawback with open surgery, and it is possible to use cost effective materials and methods in the process. |
| 主权项 |
1. A patch for treating a bone defect, comprising:
a layer comprising a primer; and a composition provided on said layer, wherein the composition comprises a reaction product of a component A and a component B, wherein component A comprises at least one compound comprising at least two thiol groups or at least one disulfide derivative of a compound comprising at least two thiol-groups, component B comprises at least two vinyl reactive groups chosen from vinyl, acrylates, methacrylates, allyl and unsaturated cyclic vinyls, and at least one compound of component A or of component B comprises at least one group selected from a hydroxyl group, a carboxyl group, a dopamine group and a phenol group; and the primer is a compound comprising a phenol group and one group selected from acrylate, methacrylate, an allyl, a vinyl and an unsaturated ring and wherein the phenol group is selected from p-hydroxyl phenyl, 3,5-dihydroxyphenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 2,4-dihydroxyphenyl, 2,5-dihydroxyphenyl, 3,4-dihydroxyphenyl, 3,5-dihydroxyphenyl and 3,4,5-trihydroxyphenyl. |
