Methods for determining total body skeletal muscle mass

摘要

The present invention is based on the finding that enrichment of isotope-labeled creatinine in a urine sample following oral administration of a single defined dose of isotope-labeled can be used to calculate total-body creatine pool size and total body skeletal muscle mass in a subject. The invention further encompasses methods for detecting creatinine and isotope-labeled creatinine in a single sample. The methods of the invention find use,