发明名称 |
HIGHLY-FUNCTIONAL MUTANT OF HUMANIZED ANTI-EGFR ANTIBODY VARIABLE REGION |
摘要 |
<p>[Problem] Disclosed is an antibody that exhibits excellent cytotoxicity and cell growth inhibition and that is based on an anti-human epithelial cell growth factor receptor (1) (Her1) antibody (528). Further disclosed is a method for producing same, and the like. [Solution] The mutant of an H chain humanized variable region (5H) or an L chain humanized variable region (5L) of the anti-human epithelial cell growth factor receptor (1) (Her1) antibody (528) is the aforementioned antibody characterized by having one to a plurality (for example: 1 to 5, or 1 to 3) of amino acid mutations within CDR2. Further disclosed are antibody molecules containing said region, a nucleic acid molecule coding for these polypeptides, a method for producing said antibody molecules, and the like.</p> |
申请公布号 |
EP2502936(B1) |
申请公布日期 |
2016.01.06 |
申请号 |
EP20100831507 |
申请日期 |
2010.11.11 |
申请人 |
TOHOKU UNIVERSITY |
发明人 |
KUMAGAI, IZUMI;NAKANISHI, TAKESHI;ASANO, RYUTARO;UMETSU, MITSUO |
分类号 |
A61K39/00;A61P35/00;C07K16/22;C07K16/28;C07K16/46 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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