发明名称 |
SITE-SPECIFIC INSULIN CONJUGATE |
摘要 |
Provided are an insulin conjugate having improved insulin receptor binding affinity and increased activity, in which a non-peptidyl polymer and an immunoglobulin Fc region are site-specifically linked to an amino acid residue of the insulin beta chain excluding the N-terminus thereof via a covalent bond, a long-acting formulation including the same, and a preparation method thereof. The insulin conjugate of the present invention is used to provide an insulin formulation which exhibits a remarkably increased in vivo activity of the peptide. |
申请公布号 |
EP2963055(A1) |
申请公布日期 |
2016.01.06 |
申请号 |
EP20140757574 |
申请日期 |
2014.02.26 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
JANG, MYUNG HYUN;KIM, DAE JIN;HWANG, SANG YOUN;KIM, HYUN UK;JUNG, SUNG YOUB;KWON, SE CHANG |
分类号 |
A61K47/48;A61K38/28;A61P3/10;C07K14/62;C07K17/08 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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