发明名称 |
A conjugate comprising angiostatin or its fragment, the method for producing the conjugate and use thereof |
摘要 |
<p>The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms.</p> |
申请公布号 |
EP2597105(B1) |
申请公布日期 |
2016.01.06 |
申请号 |
EP20130155928 |
申请日期 |
2008.01.10 |
申请人 |
PROTGEN LTD.;TSINGHUA UNIVERSITY |
发明人 |
LUO, YONGZHANG;CHANG, GUODONG;YANG, SHULING;GAO, LEI;FU, YAN |
分类号 |
C07K17/08;A61K38/18;A61K47/48;A61P35/00;C07K1/107;C07K1/18;C07K14/515 |
主分类号 |
C07K17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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