发明名称 |
PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS |
摘要 |
<p>The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone.</p> |
申请公布号 |
EP2596007(B1) |
申请公布日期 |
2016.01.06 |
申请号 |
EP20110809373 |
申请日期 |
2011.07.20 |
申请人 |
TARO PHARMACEUTICAL INDUSTRIES LTD |
发明人 |
CHERNIAK, SIMON;CYJON, ROSA;OZER, ILANA;NUDELMAN, IGOR |
分类号 |
C07J5/00;C07J71/00 |
主分类号 |
C07J5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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