发明名称 |
TETRAHYDROIMIDAZO[1,5-D][1,4]OXAZEPINE DERIVATIVE |
摘要 |
A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving the mGluR2, such as Alzheimer's disease:
wherein R is a hydrogen atom, a C 1-6 alkyl group or the like, R 1 is a C 1-6 alkyl group, a C 1-6 alkoxy group or the like, R 2 is a halogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy group or the like, R 3 is a hydrogen atom, a C 1-6 alkyl group or the like, and R 4 is a C 1-6 alkyl group or the like. |
申请公布号 |
EP2963043(A1) |
申请公布日期 |
2016.01.06 |
申请号 |
EP20140756740 |
申请日期 |
2014.02.26 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
TAKAISHI, MAMORU;SATO, NOBUHIRO;SHIBUGUCHI, TOMOYUKI;MOTOKI, TAKAFUMI;TAKAHASHI, YOSHINORI;SASAKI, TAKEO;BRAUNTON, ALAN |
分类号 |
C07D498/04;A61K31/553;A61P25/28 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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