发明名称 |
FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS |
摘要 |
The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene. |
申请公布号 |
EP2563753(B3) |
申请公布日期 |
2016.01.06 |
申请号 |
EP20110720197 |
申请日期 |
2011.04.26 |
申请人 |
SYNAFFIX B.V. |
发明人 |
VAN DELFT, FLORIS, LOUIS;RUTJES, FLORIS, PETRUS, JOHANNES, THEODORUS;DOMMERHOLT, FREDERIK, JAN |
分类号 |
C07C33/16;A61K47/48;A61K49/00;C07C29/147;C07C29/58;C07C29/62;C07C67/347;C07C69/96;C07C271/12;G01N33/532;G01N33/58 |
主分类号 |
C07C33/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|