SELECTIVE ALFAVBETA3 RECEPTOR PEPTIDE ANTAGONIST FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS

摘要

The present invention is related to new peptide antagonists of .alpha.v.beta.3 receptor, designed on the basis of the crystal structure of integrin .alpha.v.beta.3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the .alpha.v.beta.3 receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for .alpha.v.beta.3-targeted therapy and imaging.