Chelating complex micelles drug carrier

摘要

This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.

主权项

1. A chelating complex micelle, comprising:
a ligand free metal ion core, wherein the ligand free metal ion core is a Lewis acid; and a ligand, wherein the ligand and the ligand free metal ion core bind to each other by coordinate bonds; wherein said ligand free metal ion core links a drug wherein the ligand is poly(ethylene glycol)-b-poly(glutamic acid) (PEG-b-PGA).