| 发明名称 | Phosphoramidate alkylator prodrugs | ||
| 摘要 | Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents. | ||
| 申请公布号 | US9226932(B2) | 申请公布日期 | 2016.01.05 |
| 申请号 | US201314102213 | 申请日期 | 2013.12.10 |
| 申请人 | Threshold Pharmaceuticals, Inc. | 发明人 | Matteucci Mark;Duan Jian-Xin;Jiao Hailong |
| 分类号 | A61K31/337;A61K31/675;A61K33/24;C07F9/6506;C07F9/6539;A61K31/513;A61K31/7068 | 主分类号 | A61K31/337 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A method for treating cancer, said method comprising administering to a patient in need of treatment for cancer a therapeutically effective dose of N,N′-bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester (TH302) having the formula: | ||
| 地址 | South San Francisco CA US | ||