Methods and compositions for diagnosis and prognosis of renal injury and renal failure

摘要

Disclosed are methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, disclosed are assays that detect one or more markers selected from the group consisting of Prostatic acid phosphatase, Lactotransfenin, Soluble erythropoietin receptor, Von Willebrand factor, Soluble endothelial protein C receptor, and Beta-2-glycoprotein 1 as diagnostic and prognostic biomarkers in renal injuries.

主权项

1. A method for evaluating renal status in a subject, comprising:
performing one or more assays configured to detect a kidney injury marker selected from the group consisting of Prostatic acid phosphatase, Lactotransferrin, Soluble erythropoietin receptor, Von Willebrand factor, and Soluble endothelial protein C receptor on a body fluid sample obtained from the subject by introducing a body fluid sample obtained from the subject into an assay instrument which, for each kidney injury marker being assayed, (i) contacts all or a portion of the body fluid sample with a binding reagent which specifically binds for detection the kidney injury marker being assayed and (ii) generates an assay result indicative of binding of the kidney injury marker being assayed to the binding reagent to provide one or more assay results; correlating the assay result(s) generated by the assay instrument to a likelihood that the subject is at risk of a future acute renal injury within 72 hours of the time at which the body fluid sample is obtained from the subject by using the assay result to assign the subject to a predetermined subpopulation of individuals having a known predisposition of a future acute renal injury within 72 hours; and treating the subject based on the predetermined subpopulation of individuals to which the patient is assigned, wherein the treatment comprises one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.