Short acting phenylalkylamine calcium channel blockers and uses thereof

摘要

The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods.

主权项

1. A short-acting pharmaceutical composition comprising a compound having the formula: or a pharmaceutically acceptable addition salt thereof, or any enantiomer or diastereomer thereof, wherein
each a, b, c, d, e, and f is, independently, —CH2—, —O—, —S—, or a single bond;each R11, R12, R13, R14, R15, R16, and R17 is, independently: H, lower alkyl, lower alkyl substituted with —CO2(lower alkyl), lower alkyl substituted with —CO2(lower alkoxyalkyl), lower alkyl substituted with fluorine or chlorine, lower alkoxyalkyl, lower alkoxyalkyl substituted with —CO2(lower alkyl), lower alkoxyalkyl substituted with —CO2(lower alkoxyalkyl), lower alkoxyalkyl substituted with fluorine or chlorine, or CO2R10;each R10 is, independently, lower alkyl or lower alkoxyalkyl;R18 is H or CN, or CO2R10; andR19 is H, g is a single bond, and R20 is H, wherein at least one of R11, R12, R13, R14, R15, R16, and R17, is CO2R10, lower alkyl substituted by —CO2(lower alkyl), lower alkyl substituted with —CO2(lower alkoxyalkyl), lower alkoxyalkyl substituted with —CO2(lower alkyl), or lower alkoxyalkyl substituted with —CO2(lower alkoxyalkyl).