| 发明名称 | Use of <i>Listeria </i>vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals | ||
| 摘要 | This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles. | ||
| 申请公布号 | US9226958(B2) | 申请公布日期 | 2016.01.05 |
| 申请号 | US201113876810 | 申请日期 | 2011.10.03 |
| 申请人 | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 发明人 | Harn, Jr. Donald A.;Paterson Yvonne;McEwen Lisa |
| 分类号 | A61K39/00;A61K48/00;C12N15/00;A61K39/21;A61K39/12 | 主分类号 | A61K39/00 |
| 代理机构 | Pearl Cohen Zedek Latzer Baratz LLP | 代理人 | Cohen Mark S.;Pearl Cohen Zedek Latzer Baratz LLP |
| 主权项 | 1. A method of inducing a Th1 immune response in a subject having a parasitic infection, the method comprising the step of administering to said subject a therapeutically effective dose of a Listeria vaccine vector, wherein the Listeria vaccine vector expresses and secretes an antigen fused to an additional immunogenic polypeptide or a signal sequence thereof, wherein said antigen is an infectious disease antigen, and wherein said administering produces a Th1 cell-mediated immune response in said parasite infected subject. | ||
| 地址 | Athens GA US | ||