| 主权项 |
1. A method for treating cognitive impairment in a patient suffering from Alzheimer's disease or schizophrenia comprising administering to the subject a pharmaceutical composition comprising:
i) a compound represented by Formula (I): in a pharmaceutically effective amount,
in which
R1 is a group of the formula —NR2—CO—NR3R4, —NR2—CO—CO—OR5, —NH—SO 2R6, —SO2NHR7 or —NH—CO—R8, whereR2 is hydrogen or C1-C6-alkyl,R3 and R4 are independently of one another hydrogen, Ca-C6-alkyl, C3-C8-cycloalkyl or phenyl, which is optionally substituted by up to 3 radicals independently of one another selected from the group of halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, trifluoromethyl and trifluoromethoxy, orR3 and R4 together with the nitrogen atom to which they are bonded form a 5- to 6-membered heterocyclyl,R5 is hydrogen, C1-C6-alkyl, C3-C8-cycloalkyl or aryl, where C1-C6-alkyl is optionally substituted by aryl,R6 is C1-C6-alkyl, C3-C8-cycloalkyl, 5- to 6-membered heterocyclyl, aryl or 5- to 6-membered heteroaryl, where C1-C6-alkyl is optionally substituted by aryl,R7 is hydrogen, C1-C6-alkyl, C3-C8-cycloalkyl, 5- to 6-membered heterocyclyl, aryl or 5- to 6-membered heteroaryl, where C1-C6-alkyl is optionally substituted by aryl,R8 is C3-C8-cycloalkyl, C1-C6-alkyl or phenyl, where C1-C6-alkyl is substituted by C1-C6-alkoxy and phenyl by 1 to 3 radicals independently of one another selected from the group of halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, trifluoromethyl and trifluoromethoxy,or a salt thereof; and ii) a pharmaceutically acceptable carrier. |
