Balloon catheters with fibers for delivery of therapeutic agent and methods of making the same

摘要

A medical device comprises a catheter with an expandable member, fibers extending from the outer surface of the expandable member, and therapeutic agent coated on the fibers or carried in the spaces between the fibers. Upon expansion of the expandable member, the therapeutic agent is delivered from the medical device. A surfactant may be coated on the fibers. A method of manufacturing comprises coating the outer surface of an expandable member with a metallic layer, coating the metallic layer with at least one polymeric layer, forming a plurality of holes in at least one polymeric layer, forming fibers in the holes, and removing at least one polymeric layer.

主权项

1. A medical device comprising:
a catheter with an expandable balloon mounted on the catheter, the expandable balloon having an outer surface and being expandable from an unexpanded state to an expanded state; a plurality of fibers each having a proximal end and a distal end, the proximal ends affixed to the outer surface of the expandable balloon, each fiber of the plurality of fibers circumferentially and longitudinally spaced from any adjacent fiber to define a plurality of spaces extending radially away from the outer surface of the expandable balloon to the distal ends of the plurality of fibers when the expandable balloon is in the expanded state; and a therapeutic agent carried in the spaces between the plurality of fibers; wherein upon expansion of the expandable balloon the plurality of fibers are designed to be brushed against a target site to release the therapeutic agent from the spaces between the plurality of fibers and deliver the therapeutic agent from the medical device.