发明名称 |
Method and composition for treating heart failure |
摘要 |
A method and composition for treating, preventing or ameliorating heart failure, cardiac hypertrophy, and/or myocardial dysfunction includes administering a therapeutically effective amount of a HDAC inhibitor, such as phenylbutyrate, in combination with an ACE inhibitor, such as captopril. |
申请公布号 |
US9226965(B2) |
申请公布日期 |
2016.01.05 |
申请号 |
US200812285380 |
申请日期 |
2008.10.03 |
申请人 |
U.S. DEPARTMENT OF VETERANS AFFAIRS |
发明人 |
Brooks Wesley W.;Bing Oscar H.L. |
分类号 |
A61K31/40;A61K31/235;A61K45/06;A61K31/216 |
主分类号 |
A61K31/40 |
代理机构 |
Dinesh Agarwal, P.C. |
代理人 |
Dinesh Agarwal, P.C. |
主权项 |
1. A composition for treating or preventing heart failure, comprising:
a) a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or ester thereof; and b) an angiotensin converting enzyme (ACE) inhibitor, angiotensin receptor blocker, beta adrenergic receptor blocker, or a pharmaceutically acceptable salt or ester thereof. |
地址 |
Washington DC US |