Systems and methods for characterizing kidney diseases

摘要

The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.

主权项

1. A method of detecting compounds in urine, comprising:
a) providing; i) a urine sample from a subject having acute graft rejection, borderline rejection, acute tubular necrosis, or BK viral neuropathy and ii) immunoassay reagents for detection of compounds comprising osteoprotogerin and at least one compound from the list comprising IP-10, MIG, and MIP-18; b) detecting the presence of osteoprotogerin and at least one of IP-10, MIG, and MIP-18 in said urine sample using said reagents, wherein the osteoprotogerin and at least one of IP-10, MIG, and MIP-18 are present at a concentration of 80 pg/ml of higher.