发明名称 |
Myonectin (CTRP15), compositions comprising same, and methods of use |
摘要 |
Disclosed is the novel myokine known as myonectin (CTRP15), an isolated nucleic acid encoding the myonectin (CTRP15) gene, and the amino acid sequence encoding the myonectin (CTRP15) protein. Methods of isolation of the nucleic acid, protein, polypeptides and methods of making antibodies to the myonectin (CTRP15) protein are provided. The use of myonectin (CTRP15) in the modulation of lipid and/or glucose metabolism, suppressing the expression of autophagy genes, inhibiting LC3 lipidation and autophagosome-dependent p62 degradation, and activating the Akt/mTOR pathway is also provided. |
申请公布号 |
US9228005(B2) |
申请公布日期 |
2016.01.05 |
申请号 |
US201314373685 |
申请日期 |
2013.01.24 |
申请人 |
The Johns Hopkins University |
发明人 |
Wong Guang William;Seldin Marcus Michael |
分类号 |
A61K38/00;A61P3/06;A61K38/16;C07K1/00;C07K14/00;C07K17/00;C07K14/52;C07K14/775;A61K38/17;C07K14/47;C07K16/24 |
主分类号 |
A61K38/00 |
代理机构 |
Johns Hopkins Technology Transfer |
代理人 |
Johns Hopkins Technology Transfer |
主权项 |
1. A method of lowering circulating serum fatty acid levels in a subject, comprising administering to the subject an effective amount of C1q tumor necrosis factor (TNF) related protein 15 (CTRP15) myonectin protein or a functional portion thereof, and a pharmaceutically acceptable carrier, wherein the functional portion is the C1q/TNF-like domain of the CTRP15 myonectin protein. |
地址 |
Baltimore MD US |