Submicron particles for the treatment of radiation damage in patients

摘要

A method of treating a patient exposed to radiation before the patient is thrombocytopenic, comprising: intravenous infusion of protein spheres at a concentration of the protein spheres sufficient to reduce the morbidity and mortality of the irradiated patient, wherein the protein spheres are formed from soluble proteins without the addition of surfactants or detergents, and the protein spheres spontaneously and directly bind at least one coagulation factor without the aid of other molecules which specifically bind the at least one coagulation factor.

主权项

1. A method of treating an anxiolytic non-thrombocytopenic patient who is not exposed to ionizing radiations and has been in contact with irradiated patients exposed to an irreversibly damaging dose of ionizing radiation, said method comprising the steps of:
a) providing submicron protein spheres being formed without the addition of surfactant or detergent wherein said submicron protein spheres is made by the process comprising: adding a predetermined amount of a glutaraldehyde solution to a predetermined amount of an albumin solution to form a mixture; adding an alcohol solution to said mixture to form a suspension of said submicron protein spheres, wherein said alcohol solution comprises a predetermined amount of ethanol, a predetermined amount of a second glutaraldehyde solution, and a predetermined amount of a sodium chloride solution; dialyzing said suspension in distilled water to remove said alcohol solution from said suspension; and adding caprylate and sorbitol, and distilled water to said dialyzed suspension; and b) administering intravenously said submicron protein spheres to said patient so as to lower abnormal responses of the patient's cells to an oxidative stress, wherein said administered submicron protein spheres are sufficient to reduce the morbidity and mortality of the non-thrombocytopenic patient who had been in contact with the irradiated patients; wherein said submicron protein spheres is capable of spontaneously and directly bind at least one coagulation factor without the aid of other molecules which specifically bind said at least one coagulation factor.